Case Study By

Dr. Rania Seliem
Consultant Hematopathology
Head of the Pathology Department
Rashid Hospital, DHA
United Arab Emirates

CASE 1:

  • The patient is a 71-year-old woman with generalized lymphadenopathy with night sweats and fever. The patient had anemia (hematocrit, 22%) with normal WBC count and normal platelets. ​
  • She exhibited polyclonal hypergammaglobulinemia, moderately elevated LDH. EBV viral load was detected at 420 copies/mL.​

Do you want to perform this test? (Select Yes or No for each)

A. Chromosome analysis (karyotype)

B. Flow cytometry

C. IHC stains for CD30, CD15, EBV and CD20

D. IHC stains for, CD5, CD7, CD4 and CD8

E. IHC stains for CD21, CD23, PD1, CD10, BCL6

F. T-cell receptor gene rearrangement

What would be your diagnosis in Case I?

CASE 2:

  • An 80-year-old patient presented with a two-year history of non-pruritic, steroid-responsive rash that primarily involved the bilateral breasts and flanks. ​
  • It was biopsied on two previous occasions due to the patient’s concerns regarding possible cutaneous lymphoma. ​
  • Shortly thereafter, a palpable 12 x 8 mm breast mass​

Do you want to perform this test? (Select Yes or No for each)

A. Chromosome analysis (karyotype)

B. Flow cytometry

C. IHC stains for CD30, CD15, EBV and CD20

D. IHC stains for, CD5, CD7, CD4 and CD8

E. IHC stains for CD21, CD23, PD1, CD10, BCL6

F. T-cell receptor gene rearrangement

What would be your diagnosis in Case II?

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