Case Study By

Dr. Rania Seliem
Consultant Hematopathology
Head of the Pathology Department
Rashid Hospital, DHA
United Arab Emirates

CASE 1:

Clinical History:

  • 14 year old girl
  • Left cervical lymphadenopathy of 5 months duration​
  • Intermittent fever

Do you want to perform this test?

A. Recommend Chromosome analysis (karyotype)

B. recommend Flow cytometry

C. Repeat IHC stains for CD30, CD15, and CD45

D. request IHC stains for, CD3, CD5, CD7, CD4 and CD8

E. request Pax5, BoB 1, Oct2, ALK

F. T-cell receptor gene rearrangement

What would be your diagnosis in Case 2

CASE 2:

  • 22-year-old female, 16-day history of fevers, night sweats, nausea, and weight loss
    FBC showed leucocytosis with lymphocytosis and normal hemoglobin and platelet counts.
    Flow cytometry was performed on the peripheral blood
    ​
  • Ultrasound showed generalized lymphadenopathy, excisional biopsy of the left axillary lymph node done
    ​

What is the most likely diagnosis

Would you refer the case to a hematopathologist?

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